Back to Blog

Sep 8, 2025

Sarcoidosis and the Lungs: Understanding a Systemic Condition with Respiratory Impact

Carol Smyth

Sarcoidosis is a rare inflammatory disease that can affect multiple organs, but it most commonly involves the lungs and lymph nodes. While the exact cause remains unknown, the condition results in clusters of immune cells—called granulomas—that can interfere with normal organ function. Pulmonary sarcoidosis can lead to significant respiratory symptoms and long-term complications if not diagnosed and managed early. This article explores the causes, symptoms, diagnosis, and treatment of sarcoidosis, with a special focus on its effects on the respiratory system.

What is Sarcoidosis?

Sarcoidosis is a systemic granulomatous disease, meaning it causes the formation of granulomas—small clumps of inflammatory cells—in various tissues. The lungs are affected in over 90% of cases. Granulomas can resolve on their own or cause scarring (fibrosis), leading to reduced lung function over time.

"Sarcoidosis is sometimes called the 'great mimicker' because its symptoms overlap with many other illnesses."
— American Thoracic Society

Symptoms of Pulmonary Sarcoidosis

When sarcoidosis affects the lungs, symptoms may include:

  • Persistent dry cough

  • Shortness of breath (especially with exertion)

  • Chest pain or tightness

  • Wheezing

  • Fatigue

  • Fever or night sweats

Some patients may also experience eye, skin, or joint symptoms. In rare cases, sarcoidosis may be asymptomatic and discovered incidentally on a chest X-ray.

According to the Foundation for Sarcoidosis Research, more than 25% of patients report being misdiagnosed, often as asthma or bronchitis.

What Causes Sarcoidosis?

The exact cause of sarcoidosis is still unknown. However, scientists believe it may be triggered by an exaggerated immune response to an unknown antigen—possibly an infectious, environmental, or occupational agent—in people who are genetically predisposed.

Risk factors include:

  • Family history of sarcoidosis

  • Age 20–40

  • African American and Scandinavian descent

  • Occupational exposures (e.g., firefighters, agricultural workers)

How is Sarcoidosis Diagnosed?

Diagnosing sarcoidosis can be challenging and requires a combination of clinical evaluation, imaging, and biopsy:

  • Chest X-ray or CT scan: May show enlarged lymph nodes or lung changes

  • Pulmonary function tests (PFTs): Assess how well the lungs are working

  • Bronchoscopy with biopsy: Tissue samples from lungs or lymph nodes to confirm granulomas

  • Blood tests: May include angiotensin-converting enzyme (ACE) levels and inflammatory markers

Diagnosis also involves ruling out infections, cancer, and other inflammatory conditions.

Treatment of Pulmonary Sarcoidosis

Treatment depends on symptom severity and organ involvement. Many cases resolve without treatment, but persistent or progressive disease requires medical intervention.

Common treatments include:

  • Corticosteroids (e.g., prednisone): First-line treatment to reduce inflammation

  • Immunosuppressive medications (e.g., methotrexate, azathioprine): Used when steroids are not tolerated or effective

  • Biologic therapies: TNF-alpha inhibitors may be prescribed for severe cases

  • Oxygen therapy: For advanced lung disease

  • Pulmonary rehabilitation: To improve endurance and lung function

NIH research suggests that long-term management of sarcoidosis should balance inflammation control with minimizing treatment side effects.

How Technology is Helping

Wearable respiratory tech and telehealth are emerging as key tools in sarcoidosis care:

  • Smart spirometers and home pulse oximeters: Help track changes in lung function and oxygen saturation

  • Remote monitoring platforms: Alert healthcare providers to early signs of disease flare-ups

  • AI-supported imaging tools: Enhance detection of subtle changes in lung structure on CT scans

These tools support early intervention and personalized care, especially important for a variable condition like sarcoidosis.

Living With Sarcoidosis

Though sarcoidosis is unpredictable, many patients lead active lives with proper care. Lifestyle adjustments can also play a role in managing symptoms:

  • Avoid smoking and exposure to lung irritants

  • Stay physically active

  • Follow a balanced anti-inflammatory diet

  • Monitor symptoms and medication side effects

  • Stay up-to-date on vaccinations

Support from a multidisciplinary team—including pulmonologists, rheumatologists, and primary care providers—is crucial for ongoing care.

Final Thoughts

Sarcoidosis may be a rare and complex condition, but awareness is key to early detection and improved outcomes. If you or someone you know has unexplained respiratory symptoms, persistent cough, or abnormal chest imaging, consider discussing sarcoidosis as a possibility with a healthcare provider.

Technology continues to transform how we monitor and manage rare diseases like sarcoidosis, giving patients more control and support than ever before.

Resources

 

‹ Respiratory Superfoods: Eating Your Way to Healthier Lungs

Sound Healing and Breath: The Synergy of Vibration and Respiration ›